Tags: pharmacokinetics

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  1. 1-032-S-DigoxinElimination

    17 Aug 2018 | | Contributor(s):: Therese Shelton

    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body. This activity can be used to introduce compartmentalized...

  2. 1-131-S-CaffeineElimination

    15 Aug 2018 | | Contributor(s):: Therese Shelton

    We model the concentration of caffeine eliminated from the human body at a rate proportional to the concentration. This is a reaction in the language of pharmacokinetics -- the study of how drugs move in the body. This simple activity can be used to introduce differential equations, and it can...

  3. 1-130-S-AspirinAbsorption

    15 Aug 2018 | | Contributor(s):: Therese Shelton

    We model the amount of aspirin absorbed by the human body at a constant rate. This is a ``zero-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body. This simple activity can be used to introduce differential equations and it can be used to...

  4. 1971-BoyesEtal-Lidocaine In Man

    09 Oct 2017 | | Contributor(s):: Brian Winkel

    Boyes, R. N., D. B. Scott, P. J. Jebson, M. J. Godman, and D. G. Julian, M.D. 1971. Lidocaine in Man.  Clinical Pharmacology and Therapeutics. 12(1): 105-116.Abstract: Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of...

  5. WangEtAl-Estimating Mixed-Effects Differential Equation Models

    21 Sep 2017 | | Contributor(s):: Brian Winkel

    Wang, L., J. Cao 1 , J. O. Ramsay, D. M. Burger , C. J. L. Laporte, and J. K. Rockstroh. Estimating Mixed-Effects Differential Equation Models. Paper. 30 pp. Abstract: Ordinary differential equations (ODEs) are popular tools for modeling complicated dynamic systems in many areas. When multiple...

  6. Pharmacokinetics – Source Material

    12 Sep 2017 | | Contributor(s):: Brian Winkel

    Phamacokinetics –PHAR 7834. https://www.boomer.org/c/p4/?Loc=OUHSC33 . Accessed 11 September 2017.This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.Online ResourcesBackground Mathematical...

  7. 2004-Rescigno-Use of Pharmacokinetics Models

    11 Sep 2017 | | Contributor(s):: Brian Winkel

    Rescigno, Aldo. 2004. On the use of pharmacokinetic models. Phys. Med. Biol. 49: 4657-4676.Abstract:  Extensive use of models in pharmacology, in physiology and in radiotherapy raises some questions on the nature and utility of models in general and of compartmental models in particular. In...

  8. 2012-Koch-Modeling of Pharmacokinetic and Pharmacodynamics of Cancer and Arthritis

    10 Sep 2017 | | Contributor(s):: Brian Winkel

    Koch, Gilbert. 2012. Modeling of Pharmacokinetic and Pharmacodynamics of Cancer and Arthritis. PhD Dissertation. 118 pp.Abstract: Mathematical modeling of pharmacokinetics / pharmacodynamics (PKPD) is an important and growing field in drug development. In this work we develop preclinical PKPD...

  9. ASHP - Intro to Pharmacokinetics and Pharmacodynamics

    10 Sep 2017 | | Contributor(s):: Brian Winkel

    ASHP.  Intro to Pharmacokinetics and Pharmacodynamics . 18 pp. https://www.ashp.org/-/media/store%20files/p2418-sample-chapter-1.pdf . Accessed 10 September 2017. American Society of Health-System Pharmacists.This is the introductory Lesson 1 in an online set of materials to introduce...

  10. AccessPharmacy-Pharmacokinetics Of Drug Absorption

    09 Sep 2017 | | Contributor(s):: Brian Winkel

    AccessPharmacy (McGraw Ill). Applied Biopharmaceutics & Pharmacokinetics. Chapter 7.  Pharmacokinetics of Oral. Part of Book series at https://accesspharmacy.mhmedical.com/book.aspx?bookID=1592 .  Accessed 7 September 2017.From the web page.“The pharmacokinetics of drugs...

  11. 2014-Shafer-Pharmacokinetis Basis Targeted Controlled Infusion

    09 Sep 2017 | | Contributor(s):: Brian Winkel

    Shafer, Steven. The Pharmacokinetic and  Pharmacodynamic Basis of Target Controlled Infusion. 60 pp. https://web.stanford.edu/~sshafer/LECTURES.DIR/Notes/CCIP.DOC . Accessed on 7 September 2017. From the introduction of the paper, “Pharmacokinetics and pharmacodynamics provide...

  12. 2017-Peletier-Differential Equations First Order Applications

    09 Sep 2017 | | Contributor(s):: Brian Winkel

    Peletier, L. A.    Ordinary Differential Equations in Pharmacodynamics. Notes. 23 pp. http://www.math.leidenuniv.nl/~peletier/azcourse04.pdf . Accessed 8 September 2017.Good mix of theory, application, solution technique in a number of areas of applications of differential...

  13. 2011-Koch-Pharmacokinetic Intro Biomathematical Modeling

    09 Sep 2017 | | Contributor(s):: Brian Winkel

    Koch, Gretchen A. 2011. Mathematical Modelling of Natural Phenomena Drugs in the Classroom: Using Pharmacokinetics to Introduce Biomathematical Modeling . Preprint of artile to appear in Mathematical Modelling of Natural Phenomena.  6(6): 227-244....

  14. 1999-KhorashehEtAl-Direct Search Parameter Estimation

    08 Sep 2017 | | Contributor(s):: Brian Winkel

    Khorasheh, Farhad , Amir Mahbod Ahmadi, and Abbas Gerayeli, 1999.  Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation . J Pharm Pharmaceut Sci .2 (3):92-98.Abstract:Purpose. For simple pharmacokinetic compartmental models, analytical solution to the governing...

  15. 1969-Metzler-MathModelOfLSD

    07 Sep 2017 | | Contributor(s):: Brian Winkel

    Metzler, Carl M. 1969. A mathematical model for the pharmacokinetics of LSD effect.  Clinical Pharmacology and Therapeutics.  10(5): 737-740 Contains data on performance scores vs. plasma levels of LSD in the bloodstream for subjects in experiment. Keywords: pharmacokinetics, model,...

  16. 1971-Metzler-Usefulness Of Two Compartment Open Model In Pharmacokinetics

    07 Sep 2017 | | Contributor(s):: Brian Winkel

    Metzler, Carl M. , 1971. Usefulness of the Two-Compartment Open Model in Pharmacokinetics. Journal of the American Statistical Association, 66( 333): 49-53Abstract: Compartment models are widely used in pharmaceutical research to quantitate the kinetics of absorption, distribution, metabolism...

  17. 1975-RoddaEtAl-OneCompartmentOpenModel

    03 Sep 2017 | | Contributor(s):: Brian Winkel

    Rodda, B. E. , C. B. Sampson, and D. W. Smith. 1975.  The One-Compartment Open Model: Some Statistical Aspects of Parameter Estimation. Journal of the Royal Statistical Society. Series C (Applied Statistics). 24(3):  309-318. Abstract:  A new estimation procedure is proposed for...

  18. 2009-SuSunLiHartford-Comparment Models Pharmacokinetics

    03 Sep 2017 | | Contributor(s):: Brian Winkel

    Su, Jing,Peng Sun, Xiaodong Li and Alan H. Hartford (all at Merck & Co., Inc, North Wales, PA). 2009. Fitting Compartmental Models to Multiple Dose Pharmacokinetic  Data using SAS PROC NLMIXEDhttp://www.lexjansen.com/pharmasug/2009/sp/sp11.pdfAbstract:  Pharmacokinetic (PK)...

  19. 2008FoglerGurmen Elements of Chemical Reaction Engineering

    20 Jun 2015 | | Contributor(s):: H. Scott Fogler, M. Nihat Gurmen

    Fogler, H. Scott and M. Nihat Gurmen. 2008. Elements of Chemical Reaction Engineering:  Strategies for Creative Problem Solving. http://www.umich.edu/~elements/07chap/html/07prof5.htm. Accessed 12 March 2015.This is a website with lots of modeling information, exercises, and lessons. The...

  20. 1967-Wagner-Computers in pharmacokinetics

    20 Jun 2015 | | Contributor(s):: J. G. Wagner

    Wagner,  J. G.  1967. Computers in pharmacokinetics. Clinical Pharmacology and Therapeutics.  8(1)-Part 2:   201-218. This is a seminal paper in pharmacokinetics in which the author introduces historic notions and approaches. As can be seen from the abstract there is a...